Acoustic studies of cefotaxime sodium in aqueous medium at different temperatures and at frequency 5 MHz under atmospheric pressure

Abstract

Ultrasonic velocity (U) and density (ρ) measurements have been performed for the antibiotic Cefotaxime Sodium in aqueous solution at five temperatures: 20°C, 25°C, 30°C, 35°C, and 40°C. These experimental values were employed to compute several thermodynamic and acoustic parameters, including adiabatic compressibility (βₐ), change in adiabatic compressibility (Δβ), relative adiabatic compressibility (Δβ/β°), apparent molal volume (Φᵥ), apparent molal compressibility (Φₖ), and their respective limiting values, Φ°ᵥ and Φ°ₖ. The variation of these parameters with temperature and concentration was analyzed to explore the structure-making or structure-breaking behavior of Cefotaxime Sodium in aqueous medium. The findings provide valuable insights into solute–solvent interactions and the molecular characteristics of this β-lactam antibiotic under thermal perturbation.

Keywords: Ultrasonic velocity, Interferometer, Cefotaxime Sodium, adiabatic compressibility, apparent molal volume, Aqueous medium.