DEVELOPMENT AND EVALUATION OF MORINGA BASED IRON SUPPLEMENT FOR MANAGING IRON DEFICIENCY

Abstract

Iron deficiency is one of the most prevalent nutritional disorders worldwide, particularly affecting women and children, and is commonly managed using synthetic iron supplements that often cause gastrointestinal side effects and poor patient compliance. The present study was undertaken to formulate and evaluate a Moringa-based nutraceutical supplement as a natural, safe, and cost-effective alternative for the management of iron deficiency. Moringa oleifera leaves, known for their rich nutritional composition including high iron content and natural absorption enhancers such as vitamin C, were selected as the primary ingredient. Pre-formulation studies were carried out to assess physicochemical properties such as pH, moisture content, and iron concentration, confirming the suitability of the raw material. The formulation was developed and evaluated for standard quality control parameters including weight variation, hardness, friability, and disintegration time, all of which were found to be within acceptable limits. In-vitro dissolution studies demonstrated a sustained and gradual release of iron under simulated gastrointestinal conditions, while bioavailability studies using the dialysis method indicated higher dialyzable iron compared to standard iron supplements, suggesting improved absorption. Stability studies further confirmed that the formulation remained stable with minimal changes in physical and chemical properties over time. Overall, the findings of this study indicate that the Moringa-based nutraceutical supplement has significant potential as an effective, natural alternative for managing iron deficiency; however, further in-vivo and clinical studies are recommended to validate its efficacy and safety in human populations. :

Keywords: Moringa oleifera, Nutraceutical, Iron deficiency anemia, In-vitro evaluation, Bioavailability, Herbal supplement, Iron absorption