Badal Tanwar

https://doi.org/10.64823/ijmhs.2601002

Parkinson's disease (PD) is a progressive neurodegenerative disorder defined by the selective loss of dopaminergic neurons in the substantia nigra pars compacta. Although oxidative stress and neuroinflammation are widely accepted as core pathological drivers, no disease-modifying pharmacotherapy is currently available. The Nrf2/Keap1/ARE signaling axis represents a pivotal endogenous cytoprotective mechanism and an attractive therapeutic target. Withania somnifera (Ashwagandha) and Amomum subulatum (Large Cardamom) individually exhibit neuroprotective properties; however, their combined potential through Nrf2 modulation has not been systematically explored.